Ho Chi Minh City is probably better known as "Saigon". It is the 2nd largest city in Vietnam, but not very touristy. The few sites are mostly related to the Vietnam war with the USA, for example the war museum and the deep, narrow holes / channels, where the Vietcong hid themselves and fought.
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We have 2 tour operators that conduct 6 multi-day cruises between Ho Chi Minh City and Siem Reap with duration 9 - 15 days starting at USD 2,064.00.
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☛ Avalon... 1x River Cruiser
☛ Croisi Voyages... 2x River Cruiser
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From Siem Reap to the Mekong Delta (port-to-port cruise)
± USD 2,064.00
From the Angkor Temples to the Mekong Delta (port-to-port cruise)
± USD 2,952.00
± USD 2,411.00
From the Mekong Delta to the Angkor Temples (port-to-port cruise)
Fascinating Vietnam, Cambodia & the Mekong River (Southbound)