Miami Florida is one of the main economic centres of the USA. It also has a world-famous beach and the best weather. Cuban and Puerto Rican influence is felt here, for example Miami Sound Machine. For many this is the starting point of a great US vacation.
Orlando is known as "the theme park capital of the world" where it hosts Disney World (with Epcot Center) and others. Being in the state of Florida there is usually a lot of sun and playing golf is a serious option.
Memphis is home for music legends Johnny Cash and Elvis Presley. Graceland, home and final resting place of the King of Rock and Roll, can be found here.
New Orleans is located at the delta of the Mississippi river. It is known for it´s citizens Tow Sawyer and Huckleberry Finn, as well as a lot of classic river boats and Music in the so-called French Quarter.
Las Vegas is the show and gambling capital of the USA. World famous and featured in many, many movies. A wide variety of hotels from budget places to top-class resorts.
Los Angeles (aka. City of Angels) is the 2nd largest city in the USA and has a lot to offer, including great shopping (a la Pretty Woman), Hollywood, Venice Beach and sports (L.A. Lakers).
New York City has a few nick names, for example "The Big Apple", "The City That Never Sleeps" and "The Financial Capital of the World". We cannot list everything that there is to do in NYC, because it is too much. The basics however are the Statue of Liberty, Times Square, Broadway, Little Italy / China Town and the Empire State Building.
The Grand Canyon is really grand. When standing on the ridge of the canyon and looking 1 mile (1600m) down to the river Colorado that created all this, you do owe the river a lot of respect. It is possible to walk all the way down and back up in a day, what can be recommended.