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Tours & Trips between Panama and Guatemala.

Visit destinations like Panama City, Colon, Tocumen (Panama) & Guatemala City, Antigua Guatemala, Tikal (Guatemala).

Panama is a modern tropical country best known for the Panama Canal that connects the Atlantic and Pacific Oceans. But there is more: Rain Forests, Beaches and the San Blas Islands make for a great trip. Crossing the Darien Gap may not be for everyone... Panama may surpass Costa Rica in annual visitors.

Guatemala

About Guatemala
Guatemala is a poor country with many things to see and do. There are famous Maya-ruins near Tikal in the tropical forest. There is volcanic, picturesque Lake Atitlan with nearby Panajachel and Chichicastenango, where many locals sell their stuff on very colorful markets. Last but not least you can get 1:1 Spanish classes in the very beautiful and former capital, Antigua Guatemala.

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Search and compare Tours & Trips between Panama and Guatemala. Book at the tour operator.

We have 5 tour operators that conduct 13 group tours and private tours between Panama and Guatemala with duration 22 - 62 Days and rates starting at USD 4,029.

Coming from:: United States
Languages:: English
Must see countries:: Panama, Guatemala

International Operators (12)
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All 12 International Tours and Cruises

Google Map: Panama City to Antigua Travel Pass

Panama City to Antigua Travel Pass

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From/To: Panama City ⇒ Guatemala City
Countries (7): America, Costa Rica, France, Guatemala, Honduras, Nicaragua, Panama
Operator: Bamba Travel
Tour Type: Group Tours
Activities

Duration: 36 Days
Starting at: USD 4,029
Operator: Bamba

Starting at

USD 4,029

36 Days

Next Departure

01-Jan-2026
01-Jan-2027

Google Map: Panama City to Mexico Maya Express Pass

Panama City to Mexico Maya Express Pass

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From/To: Panama City ⇒ Cancun
Countries (7): America, Belize, Costa Rica, Guatemala, Mexico, Nicaragua, Panama
Operator: Bamba Travel
Tour Type: Group Tours
Activities

Duration: 40 Days
Starting at: USD 4,070
Operator: Bamba

Starting at

USD 4,070

40 Days

Next Departure

02-Jan-2026
01-Jan-2027

Google Map: Antigua to Panama City Travel Pass

Antigua to Panama City Travel Pass

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From/To: Antigua Guatemala ⇒ Panama City
Countries (7): America, Costa Rica, France, Guatemala, Honduras, Nicaragua, Panama
Operator: Bamba Travel
Tour Type: Group Tours
Activities

Duration: 35 Days
Starting at: USD 4,092
Operator: Bamba

Starting at

USD 4,092

35 Days

Next Departure

01-Jan-2026
01-Jan-2027

Google Map: Amazing Central America

Amazing Central America

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From/To: Antigua Guatemala ⇒ Panama City
Countries (5): Costa Rica, Guatemala, Honduras, Nicaragua, Panama
Operator: Intrepid Travel
Tour Type: Group Tours
Activities

Duration: 27 Days
Starting at: USD 4,350
Operator: Intrepid

Starting at

USD 4,350

27 Days

Next Departure

24-Jun-2026	4+
05-Jul-2026

Google Map: Panama City to Cancun Travel Pass

Panama City to Cancun Travel Pass

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From/To: Panama City ⇒ Cancun
Countries (9): America, Belize, Costa Rica, France, Guatemala, Honduras, Mexico, Nicaragua, Panama
Operator: Bamba Travel
Tour Type: Group Tours
Activities

Duration: 43 Days
Starting at: USD 4,390
Operator: Bamba

Starting at

USD 4,390

43 Days

Next Departure

01-Jan-2026
01-Jan-2027

Google Map: Cancun to Panama City Travel Pass

Cancun to Panama City Travel Pass

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From/To: Chichén Itzá ⇒ Panama City
Countries (9): America, Belize, Costa Rica, France, Guatemala, Honduras, Mexico, Nicaragua, Panama
Operator: Bamba Travel
Tour Type: Group Tours
Activities

Duration: 48 Days
Starting at: USD 4,541
Operator: Bamba

Starting at

USD 4,541

48 Days

Next Departure

02-Jan-2026
01-Jan-2027

Google Map: Mexico City to Panama City Travel Pass

Mexico City to Panama City Travel Pass

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From/To: Mexico City ⇒ Panama City
Countries (9): America, Belize, Costa Rica, France, Guatemala, Honduras, Mexico, Nicaragua, Panama
Operator: Bamba Travel
Tour Type: Group Tours
Activities

Duration: 57 Days
Starting at: USD 5,231
Operator: Bamba

Starting at

USD 5,231

57 Days

Next Departure

02-Jan-2026
01-Jan-2027

Google Map: Central American Explorer

Central American Explorer

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From/To: Panama City ⇒ Guatemala City
Countries (5): Costa Rica, Guatemala, Honduras, Nicaragua, Panama
Operator: Explore!
Tour Type: Group Tours
Activities

Duration: 25 Days
Starting at: ± USD 6,149
Operator: Explore!

Starting at

± USD 6,149

25 Days

Next Departure

11-Nov-2026

2

Google Map: Wonders of Central America

Wonders of Central America

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From/To: Panama City ⇒ Antigua Guatemala
Countries (2): Guatemala, Panama
Operator: On The Go Tours
Tour Type: Group Tours
Activities

Duration: 22 Days
Starting at: USD 6,195
Operator: On The Go

Starting at

USD 6,195

22 Days

Next Departure

01-Aug-2026
10-Oct-2026

Google Map: Total Central America: Two Months of Wild

Total Central America: Two Months of Wild

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From/To: Panama City (Round Trip)
Countries (7): Belize, Costa Rica, Guatemala, Honduras, Mexico, Nicaragua, Panama
Age Group: 18 - 39 Years
Participants: Tours for Young Adults
Operator: G Adventures
Tour Type: Group Tours
Activities

Duration: 62 Days
Starting at: USD 6,199
Operator: G Adventures

Starting at

USD 6,199

62 Days

Next Departure

28-Jun-2026
23-Aug-2026	4+

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