San Sebastian is a superb beach location just west of the Pyrenees with excellent food (tapas). It should be on everyone's itinerary.
Santiago de Compostela is the capital of Galicia and the end point of the pilgrimage "Camini de Santiago" and the apostel James should be buried here. The journey here is different from other journeys since people like to either walk or bike.
Madrid, capital of Spain and home of the royal family. The city center with great architecture is amazingly small, with nice places to enjoy local food and wines and very walkable.
The Canary Islands are politically part of Spain, but closer to Morocco. The islands are mainly volcanic with a very pleasant spring-like climate year-round.
Barcelona is capital of Catalonia and world-famous for soccer and architecture. You must visit the cathedral Sagrada Familia, designed by Gaudi, that has been under construction since 1883. Camp Nou, where FC Barcelona resides, is an experience of a different kind.
Cadiz is one of the oldest cities in Europe. It's location is quite unique, since it is surrounded almost completely by water (similar to Venice). James Bond used the city to resemble Cuba.
Jerez is known mainly for two things: 1) the bodegas for the finest Sherries and 2) the Equestrian School for ultimate horse back riding demonstrations. Add to this great weather, some flamenco and lots of orange trees and then you know something about Jerez de la Frontera.
Pamplona is best-known for its annual "running with the bulls"... Yes, these are real bulls and it is dangerous! Only the very sporty ones that have something to prove, should try this...